Refractory AGOC has limited options. Five-year survival for AGOC is <7% and, medium overall survival remains less than 1 year. Regorafenib is an oral multi-kinase inhibitor with a distinct profile, targeting angiogenic, stromal and oncogenic receptor tyrosine kinases.

INTEGRATE IIa was a double-blind placebo-controlled phase 3 trial comparing regorafenib and best supportive care (BSC) vs placebo and BSC for subjects with confirmed evaluable metastatic/locally advanced AGOC on a 2:1 randomisation, stratified by tumour location, geographic region (Asia vs rest of world), prior VEGF inhibitors, in patients who failed ≥ 2 prior therapies.


Prof Nick Pavlakis
Royal North Shore Hospital


Wednesday, 15 November

Session 1: Upper GI and HPB Cancer (Advanced)

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Study schema